DMPK In vivo CTG repeat contractions Hypoxia Muscle DM1 Glial cells Animals Cell model Fibrosis CRISPR/Cas9 Centronuclear myopathy Quantitative microdialysis Neuron Cell penetrating peptide Oligodendrocytes Myotonic dystrophy Glucocorticoids Mice Cytoskeleton Myotonic Dystrophy type 1 CTG repeat instability Glutamate Mouse model Brain Cardiac muscle Trinucleotide Repeat Expansion Antisense oligonucleotide Dystrophie myotonique Transcriptomics KNOCKOUT MICE Exercise Myostatin Dystrophin CTG repeats Mouse models Aging CMS CRISPRi Genotype phenotype correlation Myotonic dystrophy mouse models Myotonic Dystrophy Type 1 Dystrophie Myotonique Central nervous system RNA splicing Muscular dystrophy Intermediate filament Transgenic mouse Desmin Dilated cardiomyopathy Gene Therapy Glucocorticoid-receptor Brain dysfunction Dynamin 2 AAV Endurance training Acetylcholinesterase knockout mouse Myotonic Dystrophy RNA biology Thérapie génique Gene therapy ARN MBNL Autophagy Acetylcholinesterase deficiency Long read sequencing Diaphragm Male Expression Heart Myelin Astrocyte Therapy Cell culture model Heart failure PCR Transgenic mouse model BIOLOGIE MOLECULAIRE GSK3␤ Antisense oligonucleotides CONGENITAL MYATHENIC SYNDROME Maximal force PacBio Motoneuron Astrocytes Oligodendrocyte DMSXL mice Acute coronary syndrome Trinucleotide repeat expansion Skeletal muscle ACETYLCHOLINESTERASE Myotonic dystrophy type 1 GABA Duchenne muscular dystrophy Gene editing Exercice Humans Alternative splicing Knockout RNA interference