Nearly water-saturated argillite samples (initial water content near 3.4 wt%) were cored from an undisturbed area of an underground facility of the French Institute for Radioprotection and Nuclear Safety (IRSN), located at Tournemire (Aveyron, France). These samples were subjected to the following desiccation path: (a) A desaturation phase during which the samples were dried at ambient temperature conditions, relative humidity equal to 43% in average and (b) a heating phase during which the same samples were heated at four temperature levels from 70°C up to 105°C. During both phases, the low-frequency complex resistivity (0.18Hz–12 kHz) was recorded by a four-electrode device. The amplitude of the complex resistivity was extremely sensitive to water content change. At the end of the isotherm desaturation phase, it was multiplied by a factor of 3 to 5. During the heating phase, the resistivity increased by more than two orders of magnitude compared to the initial state. The percentage of Frequency Effect shows a low sensitivity to water content changes during the desaturation stage while it increased by two orders of magnitude during the heating phase. This result confirms that low-frequency spectral signature is extremely sensitive to textural changes (i.e., thermal-induced microcracking in this case) that occurred during heating. Moreover, the complex resistivity of the samples shows a strong anisotropy (a ratio of 10 between both amplitudes measured in the perpendicular directions). The classical Cole-Cole model cannot be used to fit the experimental data obtained in the heating phase. A generalized formulation of this model is required and was successfully applied to represent the complex resistivity data.