This study on the Cap Canaille cliff (N 43.19°, E 5.55°, Cassis, SE France) combines cosmic ray exposure (CRE) dating using two cosmogenic nuclides (in situ-produced 10Be and 36Cl) and morphological analyses to gain a better understanding of a major coastal cliff collapse event. Morphological analysis reveals evidence (cliff morphology, presence of big collapsed blocks) of a possible major collapse of Cap Canaille in the past. Aerial pictures and GIS software allow estimation of a potential collapsed volume of at least 7 × 106 m3, of which roughly 6 × 106 m3 fell into the Mediterranean Sea. In situ-produced 10Be and 36Cl concentrations were measured in samples collected on collapsed block surfaces and in situ-produced 10Be was measured along the cliff face to date the last major collapse event. Statistical analysis of the CRE ages calculated from cliff samples shows that these ages cluster around 3.5 and 6.7 ka, suggesting the existence of a two-step past major collapse. The older ages obtained (at 9 and 12 ka) coincides with the approach of present day sea level, implying a control of sea level on the cliff retreat. The CRE ages calculated from collapsed block samples are more scattered (toward younger ages) due to several geomorphological factors. The estimated collapsed volume associated with the last major collapse around 3.5 ka seems sufficient to have triggered a local tsunami in the Cassis Bay, if it fell at once into the sea.