Pharmaceutical products (PPs) represent nowadays a common pollution in aquatic environments. The PPs consumption have increased decade after decade all over the world leading to a pollution of numerous water compartments whereas no efficient water treatment has been done. Indeed, actual Waste-Water Treatment Plants (WWTPs) show limited solution in the removal of emerging organic micro-pollutants. A complete improvement of water treatment could be realistic if the associated treatment costs are controlled, Results of such unsuitable treatment drives to a constant overflow of numerous micro-pollutants, including PPs in natural waters. Today, this spillage has well-documented consequences on the biota, the human health, various ecosystems and shows a severe environment impact in general (Fent et al., 2006). Drugs concentrations vary between µg.L-1 and some ng.L-1. The entire aqueous environments are actually contaminated as shown by the abundant and various scientific publications on this subject. Namely, effluents of WWTP's (Kostich et al., 2014), river waters (Loos et al., 2009), groundwater (Lapworth et al., 2012), marine waters (McEneff et al., 2014) and sediments (Petrović et al., 2001). The ability of sediments and more particularly organic matter (OM) and the clay fraction to trap some drugs has been highlighted with the warning study on hormones. From the numerous studies led on this environmental problematic, mineralogy of clay and the nature of organic matter are the main actors for the sequestration/adsorption of emerging organic pollutants(Stein et al., 2008). Therefore, two different natural matrices were chosen in this study: sewage sludge of a rural phytoplanted filter and natural sediments in an urban system.