The objective of the Transform Source to Sink Project (TS2P) is to link the dynamics of the erosion of theWest African Craton to the offshore sedimentary basins of the African margin of the Equatorial Atlantic at geological time scales. This margin, alternating transform and oblique segments from Guinea to Nigeria, shows a strong structural variability in the margin width, continental geology and relief, drainage networks and subsidence/accumulation patterns. We analyzed this system combining onshore geology and geomorphology as well as offshore sub-surface data. For the Cenozoic, mapping and regional correlation of dated lateritic paleo-landscape remnants allows us to reconstruct two physiographic configurations of West Africa. These geometries show that the present-day drainage organization stabilized by at least 29 Myrs ago (probably by 34 Myr) revealing the antiquity of the Senegambia, Niger and Volta catchments toward the Atlantic as well as of the marginal upwarp currently forming a continental divide. The drainage rearrangement that lead to this drainage organization was primarily enhanced by the topographic growth of the Hoggar swell and caused a major stratigraphic turnover along the Equatorial margin of West Africa. Elevation differences between paleo-landscape remnants give access to the spatial and temporal distribution of denudation for 3 time-increments since 45 Myrs. From this, we estimate the volumes of sediments and associated lithologies exported by the West African Craton toward different segments of the margin, taking into account the type of eroded bedrock and the successive drainage reorganizations. For the Mesozoic, we produced paleogeographic maps at the scale of West Africa spanning the continental domain and offshore basins since 200 Ma. Mapping spatial and temporal distribution of domains either in erosion (sources) or in accumulation (sinks) document the impact of the successive rifting of Central and Equatorial Atlantic on the physiography of the area. We use low temperature thermochronology dating along three transects perpendicular to the margin (Guinea, Ivory Coast and Benin) to determine periods of maximum denudation. We compare these data to accumulation histories in passive margin basins and discuss their stratigraphic expression according to the type of margin segment they are preserved in.