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              <p>We analyze the ozone (O&lt;sub&gt;3&lt;/sub&gt;) variability in the troposphere (from ground to 300 hPa) using eight years (January 2008 – March 2016) of O&lt;sub&gt;3&lt;/sub&gt; profile measurements provided by the Infrared Atmospheric Sounding Interferometer (IASI) onboard the MetOp satellite. The capability of IASI to monitor the year-to-year variability in that layer is examined first in terms of vertical sensitivity, a priori contribution and correlations in the deseasonalized anomalies with the upper layers. We present global patterns of the main geophysical drivers (e.g. solar flux - SF, Quasi-Biennial Oscillations - QBO, North Atlantic Oscillation - NAO, El Niño/Southern Oscillation - ENSO) of IASI O&lt;sub&gt;3&lt;/sub&gt; variations, obtained by applying appropriate annual and seasonal multivariate regression models on time series of spatially gridded averaged O&lt;sub&gt;3&lt;/sub&gt;. The results show that the models are able to explain most of the O&lt;sub&gt;3&lt;/sub&gt; variability captured by IASI. Large O&lt;sub&gt;3&lt;/sub&gt; changes in the North Arctic/Euro-Atlantic sector and over the equatorial band are attributed to the NAO and the QBO effects, respectively. ENSO is modeled as the main contributor to the O&lt;sub&gt;3&lt;/sub&gt; variations in the tropical band where direct effects of warm and cool ENSO phases are highlighted with a clear tropical-extratropical gradient. A strong West-East gradient in the tropics is also found and likely reflects an indirect effect related to ENSO dry conditions. Finally, we also show that the ENSO perturbs the O&lt;sub&gt;3&lt;/sub&gt; variability far from the tropics into mid- and high latitudes where a significant 4-month time-lag in the response of O&lt;sub&gt;3&lt;/sub&gt; to ENSO is identified for the first time.</p>
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