In the last years, due to the rapid progress of technology, new materials at nanometric scale with special properties have become a flourishing field of research in materials science. The unique physicochemical properties of materials induced by various parameters such as mean size, shape, purity, crystallographic structure, and surface can generate effective solutions to challenging environmental and biomed-ical problems. As a result of this approach a large number of techniques were developed that enable obtaining novel materials at nanometric scale with specific and reproducible properties and parameters. Below will be highlighted studies on promising properties on the applicability of new materials that could lead to innovative applications in the medical field. Therefore, this special issue is focused on expected advances in the area of functionalized materials at nanometric scale. Due to multidisciplinarity of this topic, this special issue is comprised of a wide range of original research articles as well as review papers on the design and synthesis of functionalized nanomaterials, their structural, morphological, and biological characterization, and their potential uses in medical and environmental applications