The numerous non-sulfide zinc ore deposits were the historical basis for the development of zinc mining in Iran. They include the Mehdiabad, Irankouh and Angouran world-class deposits, as well as the Zarigan and Haft-har deposits. These deposits were formed by supergene oxidation of primary sulfide minerals during the complex interplay of tectonic uplift, karst development, changes in the level of the water table, and weathering. Zn (Pb) carbonates, Zn-hydrosilicates and associated hydrated phases directly replace the primary ore bodies or fill cavities along fractures related to uplift tectonics. Direct replacement of primary sulfides is accompanied by distal precipitation of zinc non-sulfide minerals in cavities or internal sediments filling. The mineralogy of the non-sulfide mineralization in all six deposits is generally complex and consists of smithsonite, hydrozincite, and hemimorphite as the main economic minerals, accompanied by iron and manganese oxy-hydroxides and residual clays. Commonly, non-sulfide minerals in these deposits consist of two types of ore: red zinc ore (RZO), rich in Zn, Fe, Pb-(As) and white zinc ore (WZO), typically with very high zinc grades but low concentrations of iron and lead. Typical minerals of the RZO are Fe-oxyhydroxides, goethite, hematite, hemimorphite, smithsonite and/or hydrozincite and cerussite. Common minerals of the WZO are smithsonite or hydrozincite and only minor amounts of Fe-oxyhydroxides and hemimorphite. Ó 2017, China University of Geosciences (Beijing) and Peking University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).