Using in-situ LA-ICP-MS, the trace-elements compositions of hydrothermal quartz from five Sb mineralized Variscan districts, from different parts of France, were compared. Each of these districts is characterized by the presence of stibnite, with quartz being an ubiquitous gangue mineral. The resulting dataset was processed using a set of multivariate statistical analyses (i.e. principal component analysis, hierarchical cluster analysis, and permutational multivariate analysis of variance). This approach highlights differences in ore-forming processes (e.g., fluid chemistry), recorded in the trace-elements pattern of the gangue minerals. Using this methodology, we could distinguish different mineralizing events with intricate paragenesis, such as those in the Sioule nappe, which appear to have recorded two different events of Sb precipitation. Results indicate that Sb incorporation in quartz is weakly correlated to other trace elements, but that its contents increase sharply in quartz from stibnite-bearing veins. In this case, Sb shows values >10 ppm and up to 200 ppm, considerably higher than the values measured in quartz unrelated to Sb mineralization (mainly ≤ 1 ppm). Intermediate Sb contents in quartz would point to the potential for a fluid to precipitate Sb ore. It is concluded that incorporation of Sb in quartz can be confidentially correlated to its content in the mineralizing fluid. Based on our data from five Sb districts of the French Variscan belt, supported by published Sb trace-elements data in quartz from a number of other Sb deposits worldwide, this study highlights the strong potential of the Sb content in quartz as a proxy for tracing Sb mineralization.