After 18 years in orbit Mars Express remains one of ESA's most scientifically productive Solar System missions, with a publication record now exceeding 1450 papers. Characterization of the surface geology on a local-to-regional scale by HRSC, OMEGA and partner experiments on NASA spacecraft has allowed constraining land-forming processes in space and time. Recent studies characterized the geology of Jezero crater in great detail and provided Digital Elevation Model (DEM) of several equatorial regions at 50 m/px resolution. New maps and catalogues of surface minerals with 200 m/px resolution were released. MARSIS radar published new observations and analysis of the multiple subglacial water bodies underneath the Southern polar cap. Modelling suggested that the "ponds" can be composed of hypersaline perchlorate brines. Spectrometers and imagers SPICAM, PFS, OMEGA, HRSC and VMC continue adding to the longest record of atmospheric parameters such as temperature, dust loading, water vapor and ozone abundance, water ice and CO₂ clouds distribution and observing transient phenomena. More than 27,000 ozone profiles derived from SPICAM UV spectra obtained in MY#26 through MY#28 were assimilated in the OpenMARS database. A new PFS "scan" mode of the spacecraft was designed and implemented to investigate diurnal variations of the atmospheric parameters. Observations of Tharsis region and Hellas basin contribute to mesoscale meteorology. ASPERA measurements together with MAVEN "deep dip" data enabled assessment of the conditions that lead to the formation of the dayside ionopause in the regions with and without strong crustal magnetic fields suggesting that the ionopause occurs where the total ionospheric pressure (magnetic + thermal) equals the upstream solar wind dynamic pressure. In 2021 Mars Express successfully performed two types of novel observations. In egress-only radio-occultations a two-way radio link was locked at a tangent altitude of about 50 km. This is well below the ionospheric peak and would allow perfect sounding of the entire ionosphere thus doubling the number of ionospheric soundings. MEX and TGO performed several test UHF occultations. The dual-spacecraft radio-occultation technique would allow much broader spatial distribution of the mission's radio occultation profiles. Mars Express is extended till the end of 2022. A science case for the mission extension till the end of 2025 will be developed and submitted in March 2022. The talk will give the Mars Express status, review the recent science highlights, and outline future plans including synergistic science with TGO and other missions.