A Cretaceous paleo-accretionary wedge, the Ashin Complex, now exposed along the Zagros suture zone in southern Iran, exhibits mafic, metasedimentary and ultramafic lithologies. Field, geochemical and petrological observations point to an anomalous high-temperature event that gave rise to the formation of peritectic (trondhjemitic) melts associated with restitic garnet-bearing amphibolites. Lu-Hf isotopic dating of centimetre-sized garnet in amphibolite-facies metasediments yielded a crystallization age of 113.10 ± 0.36 Ma, possibly representing the age of prograde to near-peak metamorphic conditions. SHRIMP U-Th-Pb zircon dating from trondhjemitic leucosomes yields crystallization ages of 104 ± 1 Ma, interpreted as the age of the temperature peak, which occurred in the upper amphibolite-facies (c. 650-680 °C at 1.1-1.3 GPa), according to thermodynamic modelling and Ti-in-zircon thermometry. Rutile crystals from two leucosomes yield Zr-in-rutile temperatures in the range of 580-640 °C and a LA-ICP-MS U-Pb age range from 85 to 112 Ma, interpreted as a consequence of partial re-equilibration during incipient cooling. A late static recrystallization event is indicated by the presence of sodic-calcic clinopyroxene, sodic amphibole, Si-rich phengite, titanite overgrowths after rutile and lawsonite within former leucosomes and late fractures. This mineral assemblage is a typical blueschist-facies (high pressure-low temperature) paragenesis and is interpreted as reflecting long-term isobaric cooling that occurred until the end of the Cretaceous as a consequence of increasing slab thermal age. This first report of a melting event in the Zagros paleo-accretionary wedge reveals the presence of a transient, abnormally high thermal gradient of c. 18 °C/km that occurred at c. 105-113 Ma. We speculate that this could be explained by the subduction of a thermal anomaly such as a seamount chain, a transform fault system or, more likely, a spreading ridge under the southern Iranian margin. Indeed, paleogeographic reconstructions of the Tethyan realm suggest the entrance of the Northern Tethyan basin ridge into the subduction zone shortly after 120 Ma.