Newly-formed clay minerals in fault zones can provide crucial information about conditions, mechanisms, and timing of deformation at low-grade metamorphism. The present study focuses on the major Lakora thrust in the west-central Pyrenees, that exposes an assemblage of Paleozoic-Upper Cretaceous rocks of the North Pyrenean Zone in the hanging wall and Campanian-Maastrichtian turbidites of the Axial Zone cover in the footwall. Detailed structural, petrological, mineralogical, and chemical investigations were performed on fault rock samples from the Lakora thrust footwall to unravel the deformation conditions related to thrusting. In addition, an attempt to date the thrust activity was made through direct ⁴⁰Ar/³⁹Ar step-heating on different fractions of muscovite/illite. The structural and petrographic observations suggest a brittle-ductile deformation in two stages along the fault zone: a first stage of bedding-parallel extension and bedding-perpendicular shortening that is marked by boudinage associated with a bedding-parallel cleavage (S0-S1) and a second stage of oblique shearing as marked by reverse faults, folds and oblique cleavage (S2). Pressure-solution and dissolution-recrystallization in the presence of fluids are the main deformation mechanisms that enhanced the neoformation of chlorite and illite associated with cleavage development during the two stages of deformation. The crystallinity, polytypism, and chemistry of illite show that the synkinematic clay minerals with the S2-stage formed under upper anchizone conditions (∼250-300 °C). Such thermal conditions are higher than those expected from the inferred maximal burial (∼6 km), thus arguing for a possible circulation of hot fluids along the thrust footwall. ⁴⁰Ar/³⁹Ar step-heating results confirm that the newly-formed illite is more abundant in the finer fractions of the most deformed sample, with a total gas age of c. 61.7 ± 0.5 Ma in the finest <0.2 μm fraction. This age is older than the early-mid Eocene age expected from structural constraints for the emplacement of the Lakora thrust sheet due to the mixing of newly-formed illites with small amounts of inherited micas and/or contamination by excess argon carried by fluids.