Before arriving at Mercury in December 2025, BepiColombo experiences multiple Venus and Mercury flybys. The second Mercury flyby was on 23 June 2022. The closest approach was at an altitude of about 200 km from Mercury's surface, and BepiColombo approached Mercury's magnetosphere from the dusk-side tail, crossed the low-altitude regions in the dawn-side southern hemisphere, and exited the magnetosphere on the dayside in the southern hemisphere.

Although the MOSIF (MMO Sunshield and Interface Structure) blocked most of the MPPE sensor's field of view until arrival at Mercury, all the MPPE sensors except HEP-ion were turned on to observe Mercury's magnetosphere during the Mercury flybys.

During the second Mercury flyby, MEA and MIA succeeded in observing energy spectra of low energy electrons and ions in the Mercury magnetosphere. In-bound and out-bound magnetopause were identified by MEA and MIA, where multiple crossings of the magnetopause were observed at the in-bound magnetopause, and single sharp magnetopause crossing was observed at the out-bound magnetopause. Inverted-V like signatures were observed by MEA in the magnetosphere. MSA also succeeded in observing mass identified ion energy spectra. H+, He+, and He++ were clearly identified while the energy spectra of total ions were consistent with MIA. HEP-ele detected decrease of the high-energy electrons below 190keV around the closest approach that was caused by the blockage of the high energy electrons by the planet Mercury. ENA detected two types of neutral particle signatures: one is neutrals generated by ion impact on the MOSIF and the other is natural neutrals from Mercury magnetosphere. MPPE data obtained during the second Mercury flyby show very active nature of the Mercury magnetosphere.