The role of gravity waves on microphysics of tropical cirrus clouds and air-parcel dehydration was studied using the combination of Lagrangian observations of temperature fluctuations and a 1.5D model. High-frequency measurements during isopycnal balloon flights were used to resolve the gravity-wave signals with periods ranging from a few days to 10 min. The detailed microphysical simulations with homogeneous freezing, sedimentation, and a crude horizontal mixing represent the slow ascent of air parcels in the tropical tropopause layer (TTL). A reference simulation describes the slow ascent of air parcels in the tropical tropopause layer, with nucleation occurring only below the cold-point tropopause with a small ice-crystal density. The inclusion of the gravity waves drastically modifies the vertical profile of low ice concentration and weak dehydration found during the ascent alone, with the increased ice-crystal number and size distribution agreeing better with observations. Numerous events of nucleation occur below and above the cold-point tropopause, efficiently restoring the relative humidity over ice to equilibrium with respect to the background temperature, as well as increasing the cloud fraction in the vicinity of the cold-point tropopause. The corresponding decrease in water vapor is estimated at 2 ppmv around the cold-point tropopause.