Columbite-tantalite group minerals are the most common Nb-Ta minerals. Columbite-tantalite is particularly suitable for U-Pb dating due to its high U and low common Pb contents. In situ isotopic dating of columbite-tantalite by LA-ICP-MS or SIMS requires certified reference material to properly account for potential matrix effects linked to substitutions between Nb and Ta and between Mn and Fe. Our study has two objectives: i) establish a database of reference materials for in situ U-Pb isotopic dating of columbite-tantalite minerals and ii) test the capability of SIMS to in situ U-Pb date columbite-tantalite minerals of different chemical composition. Tests of in situ U-Pb dating demonstrate that SIMS can easily be used to date columbite-tantalite minerals with errors and precisions overlapping the reference ID-TIMS age. There are, however, significant matrix effects for non-matching Nb-Ta-Fe-Mn compositions of sample and reference material. Matrix effects are highly correlated with the Ta/(Ta + Nb) ratio of columbite-tantalite, due to the significant difference in the atomic mass of Nb and Ta. The Mn/(Mn + Fe) ratio does not significantly contribute to the observed matrix effect as the two elements have similar atomic masses. The linear correlation between Ta/(Nb + Ta) and ((206Pb/238U)SIMS/(206Pb/238U)ID-TIMS) obtained for columbite-tantalite minerals of known ID-TIMS age demonstrates that the SIMS matrix-effect can be properly accounted for by using the chemical composition as determined by EMPA. The ability to measure 204Pb by SIMS also allows the use of reference materials with a small common lead contribution and to calculate accurate and precise ages for columbite-tantalite minerals with contributions of common lead.