The monthly averaged data time series of temperatures and rainfall without interruption of Conakry Airport (9.34 • N 13.37 • W, Guinea) from 1960 to 2016 were used. Inter-annual and annual changes in temperature and rainfall were investigated. Then, different models: Mann-Kendall Test, Multi-Linear-Regression analysis, Theil-Sen's slope estimates and wavelet analysis where used for trend analysis and the dependency with these climate forcings. Results showed an increase in temperature with semi-annual and annual cycles. A sharp and abrupt rise in the temperature in 1998 was found. The results of study have shown increasing trends for temperature (about 0.21 • /year). A decrease in rainfall (about −8.14 mm/year) is found since the end of 1960s and annual cycle with a maximum value of about 1118.3 mm recorded in August in average. The coherence between the two parameters and climate indices: El Niño 3.4, Atlantic Meridional Mode, Tropical Northern Atlantic and Atlantic Niño, were investigated. Thus, there is a clear need for increased and integrated research efforts in climate parameters variations to improve knowledge in climate change.