It is widely observed that mafic rocks are able to accommodate high strains by viscous flow. Yet, a number of questions concerning the exact nature of the involved deformation mechanisms continue to be debated. In this contribution, rock deformation experiments on four different water-added plagioclase-pyroxene mixtures are presented: (i) plagioclase(An60-70)-clinopyroxene-orthopyroxene, (ii) plagioclase(An60)-diopside, (iii) plagioclase(An60)-enstatite, and (iv) plagioclase(An01)-enstatite. Samples were deformed in general shear at strain rates of 3×10^-5 to 3×10^-6 s^-1, 800 °C, and confining pressure of 1.0 or 1.5 GPa. Results indicate that dissolution-precipitation creep (DPC) and grain boundary sliding (GBS) are the dominant deformation mechanisms and operate simultaneously. Coinciding with sample deformation, syn-kinematic mineral reactions yield abundant nucleation of new grains; the resulting intense grain size reduction is considered crucial for the activity of DPC and GBS. In high strain zones dominated by plagioclase, a weak, nonrandom, and geometrically consistent crystallographic preferred orientation (CPO) is observed. Usually, a CPO is considered a consequence of dislocation creep, but the experiments presented here demonstrate that a CPO can develop during DPC and GBS. This study provides new evidence for the importance of DPC and GBS in mid-crustal shear zones within mafic rocks, which has important implications for understanding and modeling mid-crustal rheology and flow.