The trigger mechanism of intermediate depth earthquakes (30 - 300 km) is a long-standing debate. Many studies showed that these seismic events nucleate along a double-seismic zone within the subducting slab. The seismic events of the lower plane coincide with the depth of major dehydration reactions in the lithospheric mantle. Consequently, it is thought that these events are related to the release of fluids. Several scenarios are currently discussed that might lead to brittle deformation. Among these are dehydration embrittlement and dehydration-driven stress transfer.Antigorite is one of the most important candidates for fluid release due to its high H2O content and stability limits within the lower Wadati-Benioff zone. The release of water through antigorite dehydration can be calculated by equilibrium thermodynamics and is mainly a function of temperature. This does, however, not account for deformation (e.g., stored internal strain energy) leading to local variations in the free energy of minerals. In this study we aim to explore the effect of shear stress on the stability of antigorite.We performed high-pressure and high-temperature experiments in a Griggs rig. We used intact drill cores of two different starting materials for our experiments: a foliated and an isotropic antigorite-serpentinite. Both starting materials did not contain relict olivine and/or orthopyroxene. We run our experiments at 620 to 650 °C with a confining pressure of 1.5 GPa and a strain rate of 10-6 s-2. Subsequent analyses of the experimental runs revealed no dehydration products within the bulk sample. However, we observed the formation of ultra-fine grained (< 100 nm) olivine and orthopyroxene along narrow zones, which are orientated 30 to 40 ° with respect to the compression axis. These zones are similar in all runs and independent of the starting material microstructure. We thus propose that shear stress localization within our cylindrical sample triggered the dehydration. Within subduction zones local variations in stress field due to mineralogical or textural heterogeneities could promote dehydration, eventually leading to seismic events through stress transfer.