Water and aqueous solution confined in restricted volumes (pore, channels, intra-solid cavities, etc) are largely encountered everywhere in nature, and their thermochemical properties define the possible driving forces of their interactions with any phase(s) of interest locally present. At given (T,Ptotal) pairs, liquids are considered to be bulk materials, except when the confinement reaches the nanometric scale. Despite this very usual choice, a growing number of evidences points to the existence of an intermediate-sized domain (1 μm - 50 nm) in which the interaction behaviors seems to change, most probably due to thermodynamic driving forces. This contribution reports on dedicated recent experiments, the measurements of which can be interpreted assuming modified reactive properties in the system.