The hydraulic conductivity of diverse organoclays was determined through percolation experiments and compared to a raw Na-montmorillonite (Na-Mt). The incorporation of surfactants even at low content drastically changes the hydraulic conductivity with a large increase of about two order of magnitude in contrast to that of Na-Mt (10-12 m s-1). Batch kinetics and equilibrium adsorption experiments confirmed the proper affinity of organoclays to a zwitterion antibiotic: the amoxicillin (AMX) which was quickly adsorbed (at a time below 30 min) at large amounts (up to 1.4 × 10-3 mol g-1). However, in percolation conditions, the significant increase of the permeability led to a short interaction time between the organoclays and the pharmaceutical. In contrast to Na-Mt for which it took age to get only one drop of AMX, leachates, resulting of a percolation through organoclays, were collected for a time below 10 min, not enough sufficient to ensure a proper removal of an antibiotic with concentration reduced by 5-80% of the initial solution.